The renewal of authorization for genetically modified cotton GHB614×LLCotton25, resistant to herbicides like glyphosate and glufosinate, is under scrutiny due to concerns over long-term health and environmental risks. Risk assessments have not adequately addressed cumulative effects or pesticide residues in food and feed. Increased use of complementary herbicides may harm biodiversity and soil health, contradicting EU pesticide reduction commitments. The European Parliament opposes the Commission’s proposal, citing a lack of scientific certainty and democratic support. A reform of the GMO approval process is demanded to align with precautionary principles.